The regular service cost for a Ducati Panigale V4 can vary depending on the service interval and the specific tasks involved. For the annual service, which includes an oil change, cleaning and lubricating the chain, and a 30-point inspection, the cost is approximately $496 to $500. This service also involves updating the bike's software, checking for any error codes, and performing a test ride to ensure the bike is safe to ride. For more extensive services, such as the 15,000-mile desmo service, the cost can be significantly higher, potentially reaching £1000 or more for labor alone, plus additional costs for parts, which could total around £1400. As for tire changes, the frequency depends on usage. Typically, tires on a Ducati Panigale V4 need to be replaced every 8,000 to 12,000 miles, depending on riding conditions. For example, the Bridgestone S22 tires, which are commonly used on this model, can last around this range, and the new S23 tires are expected to offer slightly better mileage and performance[3).