A well-maintained Porsche Panamera can last around 150,000 miles, which is a typical lifespan for a luxury vehicle of this caliber. Proper care, including regular maintenance, avoiding bad driving habits, and using quality parts, can significantly extend the vehicle's life. High mileage for a Panamera is generally considered to be above 100,000 miles, at which point serious repairs can become costly. However, some owners have reported their Panameras lasting up to 200,000 miles or more with diligent maintenance. Models from 2014 onwards are generally more reliable, having ironed out many of the issues present in earlier years such as engine and transmission problems, coolant leaks, and electronic malfunctions[5).