The Porsche Panamera's fuel efficiency varies significantly depending on the model and engine configuration. For the traditional gas-powered models, the 2023 Porsche Panamera typically achieves 18 mpg city, 24 mpg highway, and 20 mpg combined. However, the hybrid models offer substantially better fuel economy, with the 2022 Porsche Panamera 4S E-Hybrid and Turbo S E-Hybrid achieving up to 50 MPGe and 48 MPGe combined, respectively. This makes the hybrid configurations of the Panamera notably more fuel-efficient compared to the standard gas-powered versions.