Yes, girls can definitely drive Aprilia GPR 250. It is a great motorcycle for both genders, with plenty of power and easy handling. It has a lightweight frame, making it easy for smaller riders to maneuver. It also has an adjustable suspension, allowing for the rider to tailor the bike to their individual needs. Additionally, the GPR 250 is an excellent choice for beginners, due to its lower price point and forgiving nature. No matter your gender, the Aprilia GPR 250 is a great choice for anyone looking to get into the world of motorcycling.