The Ducati Panigale V4 is designed to run on high-octane fuel, with the minimum recommended octane rating specified as 90 /2. While it can technically run on normal petrol, using a higher octane fuel such as extra premium is highly recommended to optimize performance and prevent potential engine issues like detonation and carbon buildup. The engine's high compression ratio of 14.0:1 makes it more suitable for higher octane fuel to ensure optimal performance and engine longevity[5).