Isuzu Motors Ltd. is a Japanese car, commercial vehicle and heavy truck manufacturing company, headquartered in Tokyo. In 2005, Isuzu became the world's largest manufacturer of medium to heavy duty trucks.

It has assembly and manufacturing plants in the Japanese city of Fujisawa, as well as in the prefectures Tochigi and Hokkaido. Isuzu is famous for producing commercial vehicles and diesel engines - it produced 16 million diesel engines in 2003 alone, which can be found in vehicles all over the world.